ubiquitin proteasome — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T9809	E3 ligase Ligand 23		Ligand for E3 Ligase
	E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.		Ligand for E3 Ligase
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T13554	Arimoclomol maleate	BRX-220	HSP
	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.		HSP
T13553	Arimoclomol	BRX-220 free base	HSP
	Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).		HSP
T13858	RA190		Proteasome
	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.		Proteasome
T17014	TCO-NHS ester		Others , PROTAC Linker
	TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sy...		Others , PROTAC Linker
T17978	Fmoc-PEG12-NHS ester		Others , PROTAC Linker
	Fmoc-PEG12-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others , PROTAC Linker
T17719	Cbz-NH-PEG12-C2-acid		Others , PROTAC Linker
	Cbz-NH-PEG12-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others , PROTAC Linker
T17753	DBCO-mPEG (MW 5kDa)		Others
	DBCO-mPEG (MW 5kDa) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome syst...		Others
T17441	Amino-PEG9-alcohol		Others , PROTAC Linker
	Amino-PEG9-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome syste...		Others , PROTAC Linker
T74794	USP28-IN-4		DUB
	USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorect...		DUB
T67965	Torbafylline		cAMP , PI3K , PDE
	Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits t...		cAMP , PI3K , PDE
T74793	USP28-IN-3		DUB
	USP28-IN-3 is a highly selective USP28 inhibitor with an IC50 value of 0.1 μM against USP28.USP28-IN-3 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3, and UCHL5.USP28-IN-3 is cytotoxic to human ...		DUB
T77620	LMTK3-IN-1		c-Met/HGFR
	Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway. LMTK3-IN-1 has shown anticancer activity in a variety of cancer c...		c-Met/HGFR
T13892	SNIPER(TACC3)-2		Others
	SNIPER(TACC3)-2 targets TACC3 protein degradation via the ubiquitin-proteasome pathway. It induces cancer cell death.		Others
T13891	SNIPER(TACC3)-1		Others
	SNIPER(TACC3)-1 targets TACC3 protein degradation via the ubiquitin-proteasome pathway.It induces cancer cell death.		Others
T15473	Heptaethylene glycol	HO-PEG7-OH	Others
	Heptaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others
T16457	PEG3-methylamine		Others
	PEG3-methylamine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system ...		Others